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A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins.

Abstract:

The ideal fluorescent probe for bioimaging is bright, absorbs at long wavelengths and can be implemented flexibly in living cells and in vivo. However, the design of synthetic fluorophores that combine all of these properties has proved to be extremely difficult. Here, we introduce a biocompatible near-infrared silicon-rhodamine probe that can be coupled specifically to proteins using different labelling techniques. Importantly, its high permeability and fluorogenic character permit the imagi...

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Publication status:
Published

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Publisher copy:
10.1038/nchem.1546

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Journal:
Nature chemistry
Volume:
5
Issue:
2
Pages:
132-139
Publication date:
2013-02-05
DOI:
EISSN:
1755-4349
ISSN:
1755-4330
URN:
uuid:5ec4bb6b-e66e-4666-aa83-1b6e324c6d14
Source identifiers:
375796
Local pid:
pubs:375796

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