Journal article
Effect of interpregnancy interval on adverse perinatal outcomes in Southern China: a retrospective cohort study, 2000-2015
- Abstract:
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Background
In January 2016, a universal two-child policy was introduced in China. The association of interpregnancy interval (IPI) with perinatal outcomes has not previously been assessed among Chinese population. We investigated the effect of IPI after live birth on the risks of preterm delivery, and small, and large for gestational age births in China.
Methods
We conducted a cohort study among 227 352 Chinese women with their first and second delivery during 2000 to 2015. IPI was calculated as months from first live delivery to conception of the second pregnancy. Poisson regression models with robust variance were fit to evaluate associations of IPI with risk of adverse perinatal outcomes, adjusted for potential confounders.
Results
Compared to IPI of 24-29 months, IPI <18 months was associated with higher risks of preterm birth (PTB) and small for gestational age (SGA). For IPI <6 months, the adjusted relative risk (RR) for PTB and SGA were 2.04 (95% confidence interval [CI] 1.83, 2.27) and 1.43 (95% CI 1.31, 1.57), respectively. Women with IPI ≥60 months had higher risks of PTB and large for gestational age (LGA). For IPI ≥120 months, the adjusted RRs for PTB and LGA were 1.67 (95% CI 1.43, 1.94) and 1.10 (95% CI 0.97, 1.26).
Conclusions
Women with IPI <18 months after live birth had higher risk of PTB and SGA, and IPI ≥60 months was associated with higher risk of PTB and LGA. These findings may provide information to Chinese couples about the appropriate interpregnancy interval for a second pregnancy.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 596.9KB, Terms of use)
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- Publisher copy:
- 10.1111/ppe.12432
Authors
- Publisher:
- Wiley
- Journal:
- Paediatric and Perinatal Epidemiology More from this journal
- Volume:
- 32
- Issue:
- 2
- Pages:
- 131-140
- Publication date:
- 2018-01-02
- Acceptance date:
- 2017-11-12
- DOI:
- EISSN:
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1365-3016
- ISSN:
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0269-5022
- Keywords:
- Pubs id:
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pubs:746686
- UUID:
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uuid:5e6827b6-6170-4e65-aa8a-91ae4052bc0e
- Local pid:
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pubs:746686
- Source identifiers:
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746686
- Deposit date:
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2017-11-17
- ARK identifier:
Terms of use
- Copyright holder:
- John Wiley and Sons Ltd
- Copyright date:
- 2018
- Notes:
- © 2018 John Wiley and Sons Ltd. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1111/ppe.12432
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