Developmental dyslexia: genetic dissection of a complex cognitive trait.

Journal article

Developmental dyslexia, a specific impairment of reading ability despite adequate intelligence and educational opportunity, is one of the most frequent childhood disorders. Since the first documented cases at the beginning of the last century, it has become increasingly apparent that the reading problems of people with dyslexia form part of a heritable neurobiological syndrome. As for most cognitive and behavioural traits, phenotypic definition is fraught with difficulties and the genetic basis is complex, making the isolation of genetic risk factors a formidable challenge. Against such a background, it is notable that several recent studies have reported the localization of genes that influence dyslexia and other language-related traits. These investigations exploit novel research approaches that are relevant to many areas of human neurogenetics.

Authors: Fisher, S; DeFries, J

• Publication status: Published
• Journal: Nature reviews. Neuroscience
• Volume: 3
• Issue: 10
• Pages: 767-780
• Publication date: 2002-10-01
• DOI: 10.1038/nrn936
• EISSN: 1471-0048
• ISSN: 1471-003X
• Language: English
• Keywords: Dyslexia; Chromosomes, Human; Genetic Linkage; Reading; Transcription Factors; Quantitative Trait, Heritable; Forkhead Transcription Factors; Multifactorial Inheritance; Humans; Cognition Disorders; Chromosome Mapping