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Maintaining the proper connection between the centrioles and the pericentriolar matrix requires Drosophila centrosomin.

Abstract:

Centrosomes consist of two centrioles surrounded by an amorphous pericentriolar matrix (PCM), but it is unknown how centrioles and PCM are connected. We show that the centrioles in Drosophila embryos that lack the centrosomal protein Centrosomin (Cnn) can recruit PCM components but cannot maintain a proper attachment to the PCM. As a result, the centrioles "rocket" around in the embryo and often lose their connection to the nucleus in interphase and to the spindle poles in mitosis. This leads...

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Publication status:
Published

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Publisher copy:
10.1083/jcb.200704081

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Journal:
The Journal of cell biology
Volume:
178
Issue:
5
Pages:
725-732
Publication date:
2007-08-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:5e47a87f-32bb-42a6-b284-6113cef7a75b
Source identifiers:
223388
Local pid:
pubs:223388

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