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Public health impact of isoniazid-resistant Mycobacterium tuberculosis strains with a mutation at amino-acid position 315 of katG: a decade of experience in The Netherlands.

Abstract:

A previous limited study demonstrated that Mycobacterium tuberculosis isolates with a mutation at amino-acid position 315 of katG (Delta315) exhibited high-level resistance to isoniazid and were more frequently resistant to streptomycin. In the present study, isoniazid-resistant M. tuberculosis isolates from 8,332 patients in The Netherlands (1993-2002) were screened for the Delta315 mutation. Isoniazid resistance was found in 592 (7%) isolates, of which 323 (55%) carried Delta315. IS6110 res...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Journal:
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Volume:
12
Issue:
8
Pages:
769-775
Publication date:
2006-08-05
DOI:
EISSN:
1469-0691
ISSN:
1198-743X
URN:
uuid:5e1bfe22-192a-40a5-8f82-59ef2d94ebe6
Source identifiers:
113037
Local pid:
pubs:113037

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