- Abstract:
-
A previous limited study demonstrated that Mycobacterium tuberculosis isolates with a mutation at amino-acid position 315 of katG (Delta315) exhibited high-level resistance to isoniazid and were more frequently resistant to streptomycin. In the present study, isoniazid-resistant M. tuberculosis isolates from 8,332 patients in The Netherlands (1993-2002) were screened for the Delta315 mutation. Isoniazid resistance was found in 592 (7%) isolates, of which 323 (55%) carried Delta315. IS6110 res...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1469-0691.2006.01495.x
-
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- Journal:
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
- Volume:
- 12
- Issue:
- 8
- Pages:
- 769-775
- Publication date:
- 2006-08-05
- DOI:
- EISSN:
-
1469-0691
- ISSN:
-
1198-743X
- URN:
-
uuid:5e1bfe22-192a-40a5-8f82-59ef2d94ebe6
- Source identifiers:
-
113037
- Local pid:
- pubs:113037
- Copyright date:
- 2006
Journal article
Public health impact of isoniazid-resistant Mycobacterium tuberculosis strains with a mutation at amino-acid position 315 of katG: a decade of experience in The Netherlands.
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