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Travelling waves in a minimal go-or-grow model of cell invasion

Abstract:
We consider a minimal go-or-grow model of cell invasion, whereby cells can either proliferate, following logistic growth, or move, via linear diffusion, and phenotypic switching between these two states is density-dependent. Formal analysis in the fast switching regime shows that the total cell density in the two-population go-or-grow model can be described in terms of a single reaction–diffusion equation with density-dependent diffusion and proliferation. Using the connection to single-population models, we study travelling wave solutions, showing that the wave speed in the go-or-grow model is always bounded by the wave speed corresponding to the well-known Fisher–KPP equation.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.aml.2024.109209

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
ORCID:
0000-0001-9832-2697
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0002-6304-9333



Publisher:
Elsevier
Journal:
Applied Mathematics Letters More from this journal
Volume:
158
Article number:
109209
Publication date:
2024-07-04
Acceptance date:
2024-07-01
DOI:
EISSN:
1873-5452
ISSN:
0893-9659


Language:
English
Keywords:
Pubs id:
2011393
Local pid:
pubs:2011393
Deposit date:
2024-07-01

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