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Mathematical modelling of stretch-induced membrane traffic in bladder umbrella cells

Abstract:

The bladder is a complex organ that is highly adaptive to its mechanical environment. The umbrella cells in the bladder uroepithelium are of particular interest: these cells actively change their surface area through exo- and endocytosis of cytoplasmic vesicles, and likely form a critical component in the mechanosensing process that communicates the sense of 'fullness' to the nervous system. In this paper we develop a first mechanical model for vesicle trafficking in umbrella cells in respons...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.jtbi.2016.08.032

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Department:
Oxford, MPLS, Mathematical Institute
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Department:
Oxford, MPLS, Mathematical Institute
Apodaca, G More by this author
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Department:
Oxford, MPLS, Mathematical Institute
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Department:
Oxford, MPLS, Mathematical Institute
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Grant:
Kidney Imaging Cores Grant P30-DK-079307
Publisher:
Elsevier Publisher's website
Journal:
Journal of Theoretical Biology Journal website
Volume:
409
Pages:
115-132
Publication date:
2016-08-31
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
Pubs id:
pubs:642210
URN:
uri:5ddb75f2-a8db-4d07-9de5-53c579239c7c
UUID:
uuid:5ddb75f2-a8db-4d07-9de5-53c579239c7c
Local pid:
pubs:642210
Language:
English
Keywords:

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