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Epitope specificity of clonally expanded populations of CD8+ T cells found within the joints of patients with inflammatory arthritis.

Abstract:

OBJECTIVE: To investigate the hypothesis that clonality of synovial T cells from patients with rheumatoid arthritis is at least partly due to the presence of virus-specific T cells expressing a restricted repertoire of T cell receptors (TCRs). METHODS: Using fluorescently labeled HLA class I-peptide tetramers, populations of virus-specific CD8+ T cells were identified in samples of peripheral blood and synovial fluid taken from 4 patients with inflammatory arthritis. The TCR repertoire of the...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Callan, MF More by this author
Journal:
Arthritis and rheumatism
Volume:
44
Issue:
9
Pages:
2038-2045
Publication date:
2001-09-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:5dac93d4-6a97-42bf-949f-402087682460
Source identifiers:
31960
Local pid:
pubs:31960

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