Journal article
Heparan sulfate proteoglycan synthesis is dysregulated in human osteoarthritic cartilage
- Abstract:
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Osteoarthritis (OA) is a common degenerative joint disease, characterized by cartilage loss and subchondral bone remodelling in response to abnormal mechanical load. Heparan sulfate (HS) proteoglycans bind to many proteins that regulate cartilage homeostasis, including growth factors, morphogens, proteases, and their inhibitors, and modulate their localization, retention, and biological activity. Changes in HS expression and structure may thus have important consequences for joint health. We ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1016/j.ajpath.2018.11.011
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Funding
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- American Journal of Pathology More from this journal
- Volume:
- 189
- Issue:
- 3
- Pages:
- 632-647
- Publication date:
- 2018-12-14
- Acceptance date:
- 2018-11-13
- DOI:
- ISSN:
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0002-9440
Item Description
- Pubs id:
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pubs:951421
- UUID:
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uuid:5d9c33bd-2ae7-4f36-b106-d96b0a1fce2a
- Local pid:
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pubs:951421
- Source identifiers:
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951421
- Deposit date:
-
2018-12-11
Terms of use
- Copyright holder:
- American Society for Investigative Pathology
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Published by Elsevier Inc. on behalf of the American Society for Investigative Pathology. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.ajpath.2018.11.011
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