- Abstract:
-
Sleep and circadian rhythm disruption is frequently associated with neurodegenerative disease, yet it is unclear how the specific pathology in these disorders leads to abnormal rest/activity profiles. To investigate whether the pathological features of lysosomal storage disorders (LSDs) influence the core molecular clock or the circadian behavioural abnormalities reported in some patients, we examined mouse models of Niemann-Pick Type-C (Npc1 mutant, Npc1(nih)) and Sandhoff (Hexb knockout, He...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 8.6MB)
-
- Publisher copy:
- 10.1016/j.bbr.2015.10.021
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Behavioural Brain Research Journal website
- Volume:
- 297
- Pages:
- 213-223
- Chapter number:
- C
- Publication date:
- 2016-01-05
- DOI:
- EISSN:
-
1872-7549
- ISSN:
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0166-4328
- URN:
-
uuid:5d9a59ef-753d-4838-8299-61e5ec69200e
- Source identifiers:
-
574455
- Local pid:
- pubs:574455
- Language:
- English
- Keywords:
- Copyright holder:
- Richardson et al
- Copyright date:
- 2016
- Notes:
- © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Journal article
Circadian profiling in two mouse models of lysosomal storage disorders; Niemann Pick type-C and Sandhoff disease.
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Medical Research Council
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