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Circadian profiling in two mouse models of lysosomal storage disorders; Niemann Pick type-C and Sandhoff disease.

Abstract:

Sleep and circadian rhythm disruption is frequently associated with neurodegenerative disease, yet it is unclear how the specific pathology in these disorders leads to abnormal rest/activity profiles. To investigate whether the pathological features of lysosomal storage disorders (LSDs) influence the core molecular clock or the circadian behavioural abnormalities reported in some patients, we examined mouse models of Niemann-Pick Type-C (Npc1 mutant, Npc1(nih)) and Sandhoff (Hexb knockout, He...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.bbr.2015.10.021

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Medical Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Behavioural Brain Research Journal website
Volume:
297
Pages:
213-223
Chapter number:
C
Publication date:
2016-01-05
DOI:
EISSN:
1872-7549
ISSN:
0166-4328
URN:
uuid:5d9a59ef-753d-4838-8299-61e5ec69200e
Source identifiers:
574455
Local pid:
pubs:574455

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