Journal article icon

Journal article

Counterion-mediated enantioconvergent synthesis of axially chiral medium rings

Abstract:

There are few enantioconvergent reactions in which racemic substrates bearing multiple stereochemical features are converted into products with high levels of diastereo- and enantiocontrol. Here, we disclose a process for the highly enantio- and diastereoselective syntheses of medium ring lactams via an intramolecular counterion-directed C-alkylation reaction. The treatment of racemic biaryl anilides that exist as a complex mixture of enantiomers and diastereoisomeric conformers by virtue of ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1021/jacs.2c05485

Authors


More by this author
Role:
Author
ORCID:
0000-0002-3059-9830
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
ORCID:
0000-0001-5583-6460
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
University College
Role:
Author
ORCID:
0000-0002-8849-488X
Publisher:
American Chemical Society
Journal:
Journal of the American Chemical Society More from this journal
Volume:
144
Issue:
32
Pages:
14790-14797
Publication date:
2022-08-03
Acceptance date:
2022-08-03
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Pmid:
35921549
Language:
English
Keywords:
Pubs id:
1272685
Local pid:
pubs:1272685
Deposit date:
2022-11-14

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP