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Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders.

Abstract:

Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies have yet to identify statistically robust, replicated major effect genes or SNPs. We apply the principle of the SNP ratio test methodology described by O'Dushlaine et al to over 2100 families from the Autism Genome Project (AGP). Using a two-stage design we examine association ...

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Publisher copy:
10.1038/ejhg.2011.75

Authors


O'Dushlaine, C More by this author
Yaspan, BL More by this author
Parkhomenka, E More by this author
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Journal:
European journal of human genetics : EJHG
Volume:
19
Issue:
10
Pages:
1082-1089
Publication date:
2011-10-05
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
URN:
uuid:5d7d52b9-c78a-4a41-9fec-ebe5b75dad29
Source identifiers:
135007
Local pid:
pubs:135007

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