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Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020

Abstract:
Healthcare workers (n = 803) with mild symptoms were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 90 positive) and asked to complete a symptom questionnaire. Anosmia, muscle ache, ocular pain, general malaise, headache, extreme tiredness and fever were associated with positivity. A predictive model based on these symptoms showed moderate discriminative value (sensitivity: 91.2%; specificity: 55.6%). While our models would not justify presumptive SARS-CoV-2 diagnosis without molecular confirmation, it can contribute to targeted screening strategies.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2807/1560-7917.es.2020.25.16.2000508

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Publisher:
European Centre for Disease Prevention and Control
Journal:
Eurosurveillance More from this journal
Volume:
25
Issue:
16
Article number:
2000508
Publication date:
2020-04-23
Acceptance date:
2020-04-21
DOI:
EISSN:
1025-496X
ISSN:
1560-7917
Pmid:
32347200

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