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High copy number in human endogenous retrovirus families is associated with copying mechanisms in addition to reinfection.

Abstract:

There are at least 31 families of human endogenous retroviruses (HERVs), each derived from an independent infection by an exogenous virus. Using evidence of purifying selection on HERV genes, we have shown previously that reinfection by replication-competent elements was the predominant mechanism of copying in some families. Here we analyze the evolution of 17 HERV families using d(N)/d(S) ratios and find a positive relationship between copy number and the use of additional copying mechanisms...

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Publication status:
Published

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Publisher copy:
10.1093/molbev/msi088

Authors


Belshaw, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Tristem, M More by this author
Journal:
Molecular biology and evolution
Volume:
22
Issue:
4
Pages:
814-817
Publication date:
2005-04-05
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
URN:
uuid:5d6ae815-c8ee-4900-86f3-423c469ef2b0
Source identifiers:
209699
Local pid:
pubs:209699

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