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Journal article

Metabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease.

Abstract:

The overlapping clinical features of relapsing remitting multiple sclerosis (RRMS), aquaporin-4 (AQP4)-antibody (Ab) neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein (MOG)-Ab disease mean that detection of disease specific serum antibodies is the gold standard in diagnostics. However, antibody levels are not prognostic and may become undetectable after treatment or during remission. Therefore, there is still a need to discover antibody-independent biomar...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s40478-017-0495-8

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
ORCID:
0000-0002-8580-2023
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Oxford college:
Green Templeton College
ORCID:
0000-0001-5583-6460
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Publisher:
BioMed Central Publisher's website
Journal:
Acta Neuropathologica Communications Journal website
Volume:
5
Issue:
1
Pages:
95
Publication date:
2017-12-12
Acceptance date:
2017-11-13
DOI:
EISSN:
2051-5960
ISSN:
2051-5960
Pubs id:
pubs:810338
URN:
uri:5d5f5d2f-792f-471a-9879-e8647ad4ee9c
UUID:
uuid:5d5f5d2f-792f-471a-9879-e8647ad4ee9c
Local pid:
pubs:810338

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