Journal article : Review
A review of the prevention of mother-to-child transmission of human T-cell lymphotrophic virus type 1 (HTLV-1) with a proposed management algorithm
- Abstract:
- Human T cell lymphotropic virus type 1 (HTLV-1) is a human retrovirus that is endemic in a number of regions across the world. There are an estimated 5–10 million people infected worldwide. Japan is currently the only country with a national antenatal screening programme in place. HTLV-1 is primarily transmitted sexually in adulthood, however it can be transmitted from mother-to-child perinatally. This can occur transplacentally, during the birth process or via breastmilk. If HTLV-1 is transmitted perinatally then the lifetime risk of adult T cell leukemia/lymphoma rises from 5 to 20%, therefore prevention of mother-to-child transmission of HTLV-1 is a public health priority. There are reliable immunological and molecular tests available for HTLV-1 diagnosis during pregnancy and screening should be considered on a country by country basis. Further research on best management is needed particularly for pregnancies in women with high HTLV-1 viral load. A first step would be to establish an international registry of cases and to monitor outcomes for neonates and mothers. We have summarized key risk factors for mother-to-child transmission of HTLV-1 and subsequently propose a pragmatic guideline for management of mothers and infants in pregnancy and the perinatal period to reduce the risk of transmission. This is clinically relevant in order to reduce mother-to-child transmission of HTLV-1 and it's complications.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 806.2KB, Terms of use)
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- Publisher copy:
- 10.3389/fmed.2022.941647
Authors
+ National Institute for Health and Care Research
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- Funder identifier:
- https://ror.org/0187kwz08
- Grant:
- CL-2014-13-001
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Medicine More from this journal
- Volume:
- 9
- Article number:
- 941647
- Publication date:
- 2022-07-08
- Acceptance date:
- 2022-06-10
- DOI:
- EISSN:
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2296-858X
- Pmid:
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35872787
- Language:
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English
- Keywords:
- Subtype:
-
Review
- Pubs id:
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1272239
- Local pid:
-
pubs:1272239
- Deposit date:
-
2024-10-25
- ARK identifier:
Terms of use
- Copyright holder:
- Barr et al.
- Copyright date:
- 2022
- Rights statement:
- Copyright © 2022 Barr, Drysdale, Boullier, Lyall, Cook, Collins, Kelly, Phelan and Taylor. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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