Journal article

Quantifying Plasmodium vivax radical cure efficacy: a modelling study integrating clinical trial data and transmission dynamics

Abstract:: Background: Plasmodium vivax forms dormant liver stages (hypnozoites) that can reactivate weeks to months after primary infection. Radical cure requires a combination of antimalarial drugs to kill both the blood-stage and liver-stage parasites. Hypnozoiticidal efficacy of the liver-stage drugs primaquine and tafenoquine cannot be estimated directly because hypnozoites are undetectable. We aimed to estimate hypnozoit...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Ciavarella, C., Drakeley, C., Price, R., Mueller, I., & White, M. (2025). Quantifying Plasmodium vivax radical cure efficacy: a modelling study integrating clinical trial data and transmission dynamics. Lancet Infectious Diseases, 25(6), 668–677.

MLA Style

Ciavarella, C, et al. “Quantifying Plasmodium Vivax Radical Cure Efficacy: a Modelling Study Integrating Clinical Trial Data and Transmission Dynamics.” Lancet Infectious Diseases, vol. 25, no. 6, 2025, pp. 668–77.

Chicago Style

Ciavarella, C, C Drakeley, R Price, I Mueller, and M White. 2025. “Quantifying Plasmodium Vivax Radical Cure Efficacy: a Modelling Study Integrating Clinical Trial Data and Transmission Dynamics.” Lancet Infectious Diseases 25 (6): 668–77.
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Files:: Ciavarella_et_al_2025_Quantifying_Plasmodium_vivax.pdf

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Ciavarella_et_al_2025_Supplementary_materials.pdf

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Publisher copy:: 10.1016/s1473-3099(24)00689-3

Authors

+ Ciavarella, C More by this author

Role:: Author

+ Drakeley, C More by this author

Role:: Author

+ Price, R More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Tropical Medicine
Role:: Author

+ Mueller, I More by this author

Role:: Author

+ White, M More by this author

Role:: Author

+ Wellcome Trust More from this funder

Funder identifier:: https://ror.org/029chgv08
Grant:: 200909/Z/16/Z

Publisher:: Elsevier
Journal:: Lancet Infectious Diseases More from this journal
Volume:: 25
Issue:: 6
Pages:: 668-677
Publication date:: 2025-01-13
Acceptance date:: 2024-10-09
DOI:: 10.1016/s1473-3099(24)00689-3
EISSN:: 1474-4457
ISSN:: 1473-3099

Language:: English
Pubs id:: 2079240
Local pid:: pubs:2079240
Deposit date:: 2025-01-19
ARK identifier:: ark:/29072/ora_5d4178a7456e4863a16b5a6b66ac62c6

Terms of use

Copyright holder:: Ciavarella et al
Copyright date:: 2025
Rights statement:: © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.

Licence:: CC Attribution (CC BY)

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