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Journal article

The number of regulatory T cells in prostate cancer is associated with the androgen receptor and hypoxia-inducible factor (HIF)-2alpha but not HIF-1alpha.

Abstract:

BACKGROUND: Regulatory T cells (T(R)) mediate peripheral immunological tolerance and are implicated in tumor progression. Because prostate cancer is being investigated for treatment by immunotherapy, we have assessed tumor T(R) in prostate cancers. METHODS: T(R) cells were identified by FOXP3 in tissue microarrays (TMAs) from 146 radical prostatectomies and correlated with clinicopathological tumor parameters and prostatic specific antigen rise (PSA). RESULTS: Twenty of 146 tumors contained ...

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Publication status:
Published

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Publisher copy:
10.1002/pros.20538

Authors


Launchbury, R More by this author
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Journal:
The Prostate
Volume:
67
Issue:
6
Pages:
623-629
Publication date:
2007-05-05
DOI:
EISSN:
1097-0045
ISSN:
0270-4137
URN:
uuid:5d3d35d9-ee7e-4d47-964e-287067b3f413
Source identifiers:
125199
Local pid:
pubs:125199

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