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Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore.

Abstract:

The structure of the Staphylococcus aureus alpha-hemolysin pore has been determined to 1.9 A resolution. Contained within the mushroom-shaped homo-oligomeric heptamer is a solvent-filled channel, 100 A in length, that runs along the sevenfold axis and ranges from 14 A to 46 A in diameter. The lytic, transmembrane domain comprises the lower half of a 14-strand antiparallel beta barrel, to which each protomer contributes two beta strands, each 65 A long. The interior of the beta barrel is prima...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Chemical Biology
Role:
Author
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Journal:
Science (New York, N.Y.)
Volume:
274
Issue:
5294
Pages:
1859-1866
Publication date:
1996-12-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:5d2220c8-2720-4736-b78a-c18f1aea83bc
Source identifiers:
52435
Local pid:
pubs:52435

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