Journal article
Supramolecular synergy in the boundary lubrication of synovial joints
- Abstract:
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Hyaluronan, lubricin and phospholipids, molecules ubiquitous in synovial joints, such as hips and knees, have separately been invoked as the lubricants responsible for the remarkable lubrication of articular cartilage; but alone, these molecules cannot explain the extremely low friction at the high pressures of such joints. We find that surface-anchored hyaluronan molecules complex synergistically with phosphatidylcholine lipids present in joints to form a boundary lubricating layer, which, w...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 957.9KB, Terms of use)
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- Publisher copy:
- 10.1038/ncomms7497
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Funding
Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Nature Communications More from this journal
- Volume:
- 6
- Pages:
- 1-7
- Publication date:
- 2015-03-10
- Acceptance date:
- 2015-02-04
- DOI:
- EISSN:
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2041-1723
- Pmid:
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25754223
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:510067
- UUID:
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uuid:5d1ab8db-ca0e-4756-86f5-5cefc0f57968
- Local pid:
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pubs:510067
- Source identifiers:
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510067
- Deposit date:
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2018-06-19
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2015
- Notes:
- © 2015 Macmillan Publishers Limited. All rights reserved.This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/>
- Licence:
- CC Attribution (CC BY)
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