- Abstract:
-
Bcl-2 and p53 gene products (Bcl-2, p53) are important regulators of apoptosis and cell proliferation, and their immunohistochemical expression may help to identify high-risk breast cancer patients. The authors evaluated p53 and Bcl-2 immunoreactivity in 178 node-negative breast cancers (NNBC) with long-term follow-up (median, 60 months). Bcl-2 was seen in 111 (62%) cases, and was significantly associated with small tumor size, nonductal morphology, low tumor grade, estrogen-receptor (ER) pos...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0046-8177(96)90307-x
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- Journal:
- Human pathology
- Volume:
- 27
- Issue:
- 11
- Pages:
- 1149-1155
- Publication date:
- 1996-11-05
- DOI:
- EISSN:
-
1532-8392
- ISSN:
-
0046-8177
- URN:
-
uuid:5cfaec85-e165-44d6-918b-035a83577826
- Source identifiers:
-
486721
- Local pid:
- pubs:486721
- Copyright date:
- 1996
Journal article
Bcl-2 and p53 expression in node-negative breast carcinoma: a study with long-term follow-up.
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