The Rif1 protein negatively regulates telomeric TG repeat length in the budding yeast Saccharomyces cerevisiae, but how it prevents telomere over-extension is unknown. Rif1 was recently shown to control DNA replication by acting as a Protein Phosphatase 1 (PP1)-targeting subunit. Therefore, we investigated whether Rif1 controls telomere length by targeting PP1 activity. We find that a Rif1 mutant defective for PP1 interaction causes a long-telomere phenotype, similar to that of rif1Δ cells. T...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher's version
- Oxford University Press Publisher's website
- Nucleic Acids Research Journal website
- Publication date:
- Acceptance date:
- Pubs id:
- Local pid:
- Copyright holder:
- Kedziora et al.
- Copyright date:
Copyright © 2018 The Author. Published by Oxford University Press on behalf of Nucleic Acids Research.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Rif1 acts through Protein Phosphatase 1 but independent of replication timing to suppress telomere extension in budding yeast
If you are the owner of this record, you can report an update to it here: Report update to this record