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Rif1 acts through Protein Phosphatase 1 but independent of replication timing to suppress telomere extension in budding yeast

Abstract:

The Rif1 protein negatively regulates telomeric TG repeat length in the budding yeast Saccharomyces cerevisiae, but how it prevents telomere over-extension is unknown. Rif1 was recently shown to control DNA replication by acting as a Protein Phosphatase 1 (PP1)-targeting subunit. Therefore, we investigated whether Rif1 controls telomere length by targeting PP1 activity. We find that a Rif1 mutant defective for PP1 interaction causes a long-telomere phenotype, similar to that of rif1Δ cells. T...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gky132

Authors


Kedziora, S More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Clark, KRM More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Brasenose College
ORCID:
0000-0003-2001-076X
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Grant:
A19059 to A.D., S.H.
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Grant:
Investigator Award [110064/Z/15/Z to C.A.N., R.H.C.W.]
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Grant:
PhD Studentship (to S.K.)
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
46
Issue:
8
Pages:
3993–4003
Publication date:
2018-02-26
Acceptance date:
2018-02-23
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:829393
URN:
uri:5cf6f83b-6cdd-4d71-9156-d31a78ab4339
UUID:
uuid:5cf6f83b-6cdd-4d71-9156-d31a78ab4339
Local pid:
pubs:829393

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