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Vitamin D-related genes, blood vitamin D levels and colorectal cancer risk in Western European populations

Abstract:

Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, and by gene/pathway) in 86 vitamin D-related genes in 1420 incident CRC cases matched to control...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/nu11081954

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Role:
Author
ORCID:
0000-0002-7805-9913
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Role:
Author
ORCID:
0000-0002-0277-9607
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Role:
Author
ORCID:
0000-0003-1668-8770
Publisher:
MDPI
Journal:
Nutrients More from this journal
Volume:
11
Issue:
8
Article number:
1954
Publication date:
2019-08-20
Acceptance date:
2019-08-12
DOI:
EISSN:
2072-6643
ISSN:
2072-6643
Pmid:
31434255
Language:
English
Keywords:
Pubs id:
pubs:1047199
UUID:
uuid:5ce34382-cd51-4c31-9b2c-89317beac8f9
Local pid:
pubs:1047199
Source identifiers:
1047199
Deposit date:
2019-09-02

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