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Comparison Of iNfliximab and ciclosporin in STeroid Resistant Ulcerative Colitis: pragmatic randomised Trial and economic evaluation (CONSTRUCT)

Abstract:

Background: The efficacy of infliximab and ciclosporin in treating severe ulcerative colitis (UC) is proven, but there has been no comparative evaluation of effectiveness. Objective: To compare the clinical effectiveness and cost-effectiveness of infliximab and ciclosporin in treating steroid-resistant acute severe UC. Method: Between May 2010 and February 2013 we recruited 270 participants from 52 hospitals in England, Scotland and Wales to an open-label parallel-group, pragmatic randomised ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3310/hta20440

Authors


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Role:
Author
ORCID:
0000-0002-7015-9055
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Role:
Author
ORCID:
0000-0003-2590-851X
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Role:
Author
ORCID:
0000-0002-6340-8244
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-5555-433X
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Role:
Author
ORCID:
0000-0003-1968-1988


Publisher:
NIHR Journals Library
Journal:
Health Technology Assessment More from this journal
Volume:
20
Issue:
44
Pages:
1-320
Publication date:
2016-06-01
DOI:
EISSN:
2046-4924
ISSN:
1366-5278


Language:
English
Keywords:
Pubs id:
2283034
Local pid:
pubs:2283034
Source identifiers:
W2200319253
Deposit date:
2025-08-21
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