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Journal article

Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes

Abstract:

In severe falciparum malaria cytoadherence of parasitised red blood cells (PRBCs) to vascular endothelium (causing sequestration) and to uninfected red cells (causing rosette formation) contribute to microcirculatory flow obstruction in vital organs. Heparin can reverse the underlying ligand-receptor interactions, but may increase the bleeding risks. As a heparin-derived polysaccharide, sevuparin has been designed to retain anti-adhesive properties, while the antithrombin-binding domains have...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's verion

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Publisher copy:
10.1371/journal.pone.0172718

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Contributors

Role:
Editor
Wellcome Trust More from this funder
Swedish Research Council (VR) More from this funder
Swedish Foundation for Strategic Research (SSF) More from this funder
Swedish International Development Agency (SIDA) More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Issue:
3
Pages:
e0172718
Publication date:
2017-03-12
Acceptance date:
2017-02-08
DOI:
EISSN:
1932-6203
Pubs id:
pubs:683615
URN:
uri:5ccfe4ab-5522-4c3e-96f5-20e9546a0e07
UUID:
uuid:5ccfe4ab-5522-4c3e-96f5-20e9546a0e07
Local pid:
pubs:683615

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