Innate immune receptors for cross-presentation: The expanding role of NLRs

Journal article

A critical role of pattern recognition receptors (PRRs) is to influence adaptive immune responses by regulating antigen presentation. Engagement of PRRs in dendritic cells (DCs) increases MHC class I antigen presentation and CD8+ T-cell activation by cross-presented peptides but the molecular mechanisms underlying these effects are not completely understood. Studies looking at the role of PRRs in cross-presentation have been largely limited to TLRs but the role of other PRRs such as cytosolic nucleotide-binding oligomerization domain-like (NOD-like) receptors remains particularly enigmatic. Here we discuss recent evidence of the role of PRRs on cross-presentation and consider how cytosolic NLR-associated pathways, such as NOD2, may integrate these signals resulting in effective adaptive CD8+ T cells responses.

Authors: Corridoni, D; Simmons, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Molecular Immunology
• Volume: 113
• Pages: 6-10
• Publication date: 2017-11-29
• Acceptance date: 2017-11-27
• DOI: 10.1016/j.molimm.2017.11.028
• EISSN: 1872-9142
• ISSN: 0161-5890
• Pmid: 29198621
• Language: English
• Keywords: MHC class I; PRRs; NLRs; CD8+ T cells; cross-presentation