Weak antiparkinsonian activity of the D1 agonist C-APB (SKF 82958) and lack of synergism with a D2 agonist in primates.

Journal article

The role of D1 receptors in motor control is poorly understood. In parkinsonian squirrel monkeys, the full D1 agonist C-APB (SKF 82958; 0.1-0.4 mg/kg s.c.) caused weak stimulation of locomotor activity. However, the motor stimulant effects of the D2 agonist (+)-PHNO (0.001 mg/kg s.c.) were not potentiated by C-APB (0.3 mg/kg). Differences between these observations and expectations from experiments using rodents are discussed.

Authors: Rupniak, N; Boyce, S; Steventon, M; Iversen, S

• Publication status: Published
• Journal: Clinical neuropharmacology
• Volume: 15
• Issue: 4
• Pages: 307-309
• Publication date: 1992-08-01
• DOI: 10.1097/00002826-199208000-00005
• EISSN: 1537-162X
• ISSN: 0362-5664
• Language: English
• Keywords: Animals; Saimiri; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Parkinson Disease, Secondary; Motor Activity; Male; Antiparkinson Agents; Benzazepines; Dopamine Agents; Receptors, Dopamine D2; Drug Synergism; Receptors, Dopamine; Receptors, Dopamine D1