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N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models

Abstract:

Ectopic calcification (EC), which is the pathological deposition of calcium and phosphate in extra-skeletal tissues, may be associated with hypercalcaemic and hyperphosphataemic disorders, or it may occur in the absence of metabolic abnormalities. In addition, EC may be inherited as part of several monogenic disorders and studies of these have provided valuable insights into the metabolic pathways regulating mineral metabolism. For example, studies of tumoural calcinosis, a disorder character...

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Publication status:
Published
Peer review status:
Peer reviewed

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Department:
Oxford Centre for Diabetes, Endocrinology and Metabolism
Role:
Author
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Department:
Oxford Centre for Diabetes, Endocrinology and Metabolism
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Author
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Grant:
G0600702/1, G9825289 and G1000467
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE
Volume:
10
Issue:
4
Publication date:
2015-10-04
Acceptance date:
2015-11-02
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
e0122650
Language:
English

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