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Journal article

Trifunctional lipid probes for comprehensive studies of single lipid species in living cells

Abstract:

Lipid-mediated signaling events regulate many cellular processes. Investigations of the complex underlying mechanisms are difficult because several different methods need to be used under varying conditions. Here we introduce multifunctional lipid derivatives to study lipid metabolism, lipid−protein interactions, and intracellular lipid localization with a single tool per target lipid. The probes are equipped with two photoreactive groups to allow photoliberation (uncaging) and photo–cross...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1073/pnas.1611096114

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Department:
Oxford, MSD, Pharmacology
Role:
Author
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National Institutes of Health More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
114
Issue:
7
Pages:
1566–1571
Publication date:
2017-02-14
Acceptance date:
2016-12-23
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:685489
URN:
uri:5c9483b4-4cb8-4080-bce7-07d71322f5cf
UUID:
uuid:5c9483b4-4cb8-4080-bce7-07d71322f5cf
Local pid:
pubs:685489
Paper number:
7

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