Journal article
Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model of multiple sclerosis.
- Abstract:
-
Multiple sclerosis (MS) frequently starts near the lateral ventricles, which are lined by subventricular zone (SVZ) progenitor cells that can migrate to lesions and contribute to repair. Because MS-induced inflammation may decrease SVZ proliferation and thus limit repair, we studied the role of galectin-3 (Gal-3), a proinflammatory protein. Gal-3 expression was increased in periventricular regions of human MS in post-mortem brain samples and was also upregulated in periventricular regions in ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1002/glia.22906
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Authors
Bibliographic Details
- Journal:
- Glia
- Publication date:
- 2015-09-04
- DOI:
- EISSN:
-
1098-1136
- ISSN:
-
0894-1491
- Source identifiers:
-
546924
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:546924
- UUID:
-
uuid:5c834b2c-cebd-46fe-90f1-f3850ec7d16b
- Local pid:
- pubs:546924
- Deposit date:
- 2015-09-23
Terms of use
- Copyright holder:
- John Wiley and Sons, Inc
- Copyright date:
- 2015
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