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A neural circuit mechanism integrating motivational state with memory expression in Drosophila.

Abstract:

Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuropeptide F (dNPF), an ortholog of mammalian NPY, mimics food deprivation and promotes memory performance in satiated flies. Robust appetitive memory performance requires the dNPF ...

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Publisher copy:
10.1016/j.cell.2009.08.035

Authors


Krashes, MJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Armstrong, JD More by this author
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Journal:
Cell
Volume:
139
Issue:
2
Pages:
416-427
Publication date:
2009-10-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:5c7c1a5a-c3eb-4880-977e-ea56ce085b9e
Source identifiers:
237339
Local pid:
pubs:237339

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