Journal article
Fast association rates suggest a conformational change in the MHC class I molecule H-2Db upon peptide binding.
- Abstract:
-
Major histocompatibility complex (MHC) class I molecules bind peptides in the endoplasmic reticulum (ER). For this binding reaction, when performed in vitro, widely differing association rates have been reported. We have expressed empty soluble H-2Db class I molecules in Chinese hamster ovary (CHO) cells and generated complete sets of association, dissociation, and equilibrium constants of unmodified peptides using tritium-labeled peptides and stopped-flow fluorescence spectroscopy. We find t...
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- Publication status:
- Published
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- Publisher copy:
- 10.1021/bi9717441
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Authors
Bibliographic Details
- Journal:
- Biochemistry
- Volume:
- 37
- Issue:
- 9
- Pages:
- 3001-3012
- Publication date:
- 1998-03-05
- DOI:
- EISSN:
-
1520-4995
- ISSN:
-
0006-2960
- URN:
-
uuid:5c731c67-0452-4b95-87ff-77c575d94ad5
- Source identifiers:
-
8046
- Local pid:
- pubs:8046
Item Description
Terms of use
- Copyright date:
- 1998
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