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The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential

Abstract:

The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level th...

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Publisher copy:
10.1038/ni.2255

Authors


Boukarabila, H More by this author
Macaulay, IC More by this author
Buza-Vidas, N More by this author
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Journal:
Nature Immunology
Volume:
13
Issue:
4
Pages:
412-419
Publication date:
2012-04-05
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
URN:
uuid:5c70c654-7157-479a-b2f1-75dd3718dc80
Source identifiers:
341521
Local pid:
pubs:341521
Language:
English

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