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Gene regulatory networks governing the generation and regeneration of blood

Abstract:

Blood is an example of a highly regenerative tissue and its regeneration depends on the presence of stem cells residing in the bone marrow in humans. A better understanding of how these stem cells are programmed would benefit their use in clinical practice and shed light on the mechanisms by which the unique properties of stem cells are established. Our approach is to delineate the gene regulatory networks (GRNs) that specify these cells during their development in the embryo, and we use the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1089/cmb.2019.0114

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
ORCID:
0000-0002-0505-6607


Publisher:
Mary Ann Liebert
Journal:
Journal of Computational Biology More from this journal
Volume:
26
Issue:
7
Pages:
719-725
Publication date:
2019-05-29
Acceptance date:
2019-05-29
DOI:
EISSN:
1557-8666
ISSN:
1066-5277
Pmid:
31140835


Language:
English
Keywords:
Pubs id:
1004635
Local pid:
pubs:1004635
Deposit date:
2020-05-25

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