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Journal article

Prime-boost immunisation strategies for tuberculosis.

Abstract:
Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Heterologous prime-boost immunisation strategies induce higher levels of both CD4+ and CD8+ T cells than homologous boosting with the same vector. Recombinant pox-viruses are particularly good at boosting previously primed T cell responses. Using BCG as the priming immunisation in such a heterologous prime-boost strategy is a practical solution, which allows the beneficial effects of BCG in children to be maintained.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Journal:
Microbes and infection / Institut Pasteur
Volume:
7
Issue:
5-6
Pages:
962-967
Publication date:
2005-05-05
DOI:
EISSN:
1769-714X
ISSN:
1286-4579
URN:
uuid:5c1d8292-2af6-4908-8924-abe24cc0ec73
Source identifiers:
33098
Local pid:
pubs:33098

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