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Journal article

Effect of age and the APOE gene on metabolite concentrations in the posterior cingulate cortex

Abstract:

Proton magnetic resonance spectroscopy (1H-MRS) has provided valuable information about the neurochemical profile of Alzheimer's disease (AD). However, its clinical utility has been limited in part by the lack of consistent information on how metabolite concentrations vary in the normal aging brain and in carriers of apolipoprotein E (APOE) ε4, an established risk gene for AD. We quantified metabolites within an 8 cm3 voxel within the posterior cingulate cortex (PCC)/precuneus in 30 younger (...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.neuroimage.2017.03.031

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Funding agency for:
Emir, U
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Funding agency for:
Stagg, C
Grant:
102584/Z/13/Z
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Funding agency for:
Mahmood, A
Grant:
1117747
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Funding agency for:
Singh-Manoux, A
Grant:
R01AG034454
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Publisher:
Elsevier Publisher's website
Journal:
NeuroImage Journal website
Volume:
152
Pages:
509-516
Publication date:
2017-03-18
Acceptance date:
2017-03-16
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
Source identifiers:
686172
Keywords:
Pubs id:
pubs:686172
UUID:
uuid:5c02d276-a452-4e83-b75f-3fb02c876470
Local pid:
pubs:686172
Deposit date:
2017-03-16

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