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Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

Abstract:

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1000508

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Academy of Finland More from this funder
ADA Smith Family Foundation Pinnacle Program More from this funder
American Diabetes Association More from this funder
Arthritis Research Campaign More from this funder
Barts and The London Charity More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLOS Genetics Journal website
Volume:
6
Issue:
4
Article number:
e1000508
Publication date:
2010-04-01
DOI:
ISSN:
1553-7390
Source identifiers:
54833
Pubs id:
pubs:54833
UUID:
uuid:5bcf8e38-38f1-4c28-ab08-9a9f824bcbd2
Local pid:
pubs:54833
Deposit date:
2012-12-19

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