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Equine rhinitis A virus and its low pH empty particle: clues towards an aphthovirus entry mechanism?

Abstract:

Equine rhinitis A virus (ERAV) is closely related to foot-and-mouth disease virus (FMDV), belonging to the genus Aphthovirus of the Picornaviridae. How picornaviruses introduce their RNA genome into the cytoplasm of the host cell to initiate replication is unclear since they have no lipid envelope to facilitate fusion with cellular membranes. It has been thought that the dissociation of the FMDV particle into pentameric subunits at acidic pH is the mechanism for genome release during cell ent...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1000620

Authors


Tuthill, TJ More by this author
More by this author
Institution:
University of Oxford
More by this author
Institution:
University of Oxford
Knowles, NJ More by this author
Groppelli, E More by this author
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Biotechnology and Biological Sciences Research Council More from this funder
Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
5
Issue:
10
Pages:
e1000620
Publication date:
2009-10-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:5bab29dd-64bb-409c-b47a-1a53e2200ed4
Source identifiers:
24197
Local pid:
pubs:24197

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