Histamine enhances keratinocyte-mediated resolution of inflammation by promoting wound healing and response to infection.
BACKGROUND: The role of the epidermis in the immune response is well known. While multiple cytokines are implicated in keratinocyte-mediated infection clearance and wound healing, little is known about the involvement of keratinocytes in promoting resolution of inflammation. AIM: To assess effects of histamine stimulation on keratinocyte function. METHODS: We performed a combined microarray/Gene Ontology analysis of histamine-stimulated keratinocytes. Functional changes were tested by apoptos...Expand abstract
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