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Impaired nitric oxide-mediated flow-induced coronary dilation in hyperhomocysteinemia: morphological and functional evidence for increased peroxynitrite formation.

Abstract:

Hyperhomocysteinemia (HHcy) is a newly recognized risk factor for myocardial infarction, however, the effect of HHcy on endothelium-dependent flow-induced dilation of coronary arteries is not known. Thus, changes in diameter of small intramural coronary arteries (diameter, approximately 145 microm) isolated from control rats and rats with methionine diet-induced HHcy were investigated by videomicroscopy. Increases in intraluminal flow (from 0 to 40 microl/min) elicited dilations of control ve...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
The American journal of pathology
Volume:
161
Issue:
1
Pages:
145-153
Publication date:
2002-07-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:5b668f12-bb93-41f1-ad0d-538540565338
Source identifiers:
164473
Local pid:
pubs:164473

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