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The direct formation of glycosyl thiols from reducing sugars allows one-pot protein glycoconjugation.

Abstract:
(Figure Presented) Sweet and easy: A one-pot method consisting of direct thionation (1) followed by thiol-mediated chemoselective ligation (2) can be used for site-selective protein glycosylation. This procedure, which uses the Lawesson reagent, has been shown to be fully compatible with unprotected sugars, the products of which can be directly used in a selenenylsulfide protein glycosylation strategy. © 2006 Wiley-VCH Verlag GmbH and Co. KGaA.
Publication status:
Published

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Publisher copy:
10.1002/anie.200600685

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Angewandte Chemie (International ed. in English)
Volume:
45
Issue:
24
Pages:
4007-4011
Publication date:
2006-06-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:5b5d813e-d773-4fc4-85b9-12fdf7e89e97
Source identifiers:
33462
Local pid:
pubs:33462

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