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Journal article

Disambiguating pharmacological mechanisms from placebo in neuropathic pain using functional neuroimaging

Abstract:
Background: Lack of objective outcome measures and over-reliance on subjective pain reports in early proof-of-concept studies contribute to the high attrition of potentially effective new analgesics. We studied the utility of neuroimaging in providing objective evidence of neural activity related to drug modulation or a placebo effect in a double-blind, randomised, placebo-controlled, three-way, crossover trial setting. Methods: We chronically administered p... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bja.2017.11.064

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Clinical Neurosciences
Role:
Author
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National Institute for Health Research More from this funder
Medical Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
British Journal of Anaesthesia Journal website
Volume:
120
Issue:
2
Pages:
299–307
Publication date:
2017-12-13
Acceptance date:
2017-08-07
DOI:
EISSN:
1471-6771
ISSN:
0007-0912
Source identifiers:
738647
Keywords:
Pubs id:
pubs:738647
UUID:
uuid:5b5b3f73-17ec-49d3-801d-0287a901bfce
Local pid:
pubs:738647
Deposit date:
2017-10-26

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