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Journal article

Fine mapping versus replication in whole-genome association studies.

Abstract:

Association replication studies have a poor track record and, even when successful, often claim association with different markers, alleles, and phenotypes than those reported in the primary study. It is unknown whether these outcomes reflect genuine associations or false-positive results. A greater understanding of these observations is essential for genomewide association (GWA) studies, since they have the potential to identify multiple new associations that that will require external valid...

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Publication status:
Published

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Publisher copy:
10.1086/521952

Authors


Clarke, GM More by this author
Carter, KW More by this author
Palmer, LJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Cardon, LR More by this author
Journal:
American journal of human genetics
Volume:
81
Issue:
5
Pages:
995-1005
Publication date:
2007-11-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:5b5671ee-c7c8-47f1-b6b0-467a1da202d0
Source identifiers:
33997
Local pid:
pubs:33997

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