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Journal article

Fine mapping versus replication in whole-genome association studies.

Abstract:

Association replication studies have a poor track record and, even when successful, often claim association with different markers, alleles, and phenotypes than those reported in the primary study. It is unknown whether these outcomes reflect genuine associations or false-positive results. A greater understanding of these observations is essential for genomewide association (GWA) studies, since they have the potential to identify multiple new associations that that will require external valid...

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Publication status:
Published

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Publisher copy:
10.1086/521952

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
American journal of human genetics More from this journal
Volume:
81
Issue:
5
Pages:
995-1005
Publication date:
2007-11-01
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Language:
English
Keywords:
Pubs id:
pubs:33997
UUID:
uuid:5b5671ee-c7c8-47f1-b6b0-467a1da202d0
Local pid:
pubs:33997
Source identifiers:
33997
Deposit date:
2012-12-19

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