Journal article
Comparison of methods for transcriptome imputation through application to two common complex diseases
- Abstract:
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Transcriptome imputation has become a popular method for integrating genotype data with publicly available expression data to investigate the potentially causal role of genes in complex traits. Here, we compare three approaches (PrediXcan, MetaXcan and FUSION) via application to genome-wide association study (GWAS) data for Crohn's disease and type 1 diabetes from the Wellcome Trust Case Control Consortium. We investigate: (i) how the results of each approach compare with each other and with ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.4MB)
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- Publisher copy:
- 10.1038/s41431-018-0176-5
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Authors
Funding
National Institutes of Health
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- European Journal of Human Genetics Journal website
- Volume:
- 26
- Issue:
- 11
- Pages:
- 1658-1667
- Publication date:
- 2018-07-05
- Acceptance date:
- 2018-04-11
- DOI:
- EISSN:
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1476-5438
- ISSN:
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1018-4813
- Pmid:
-
29976976
- Source identifiers:
-
869151
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:869151
- UUID:
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uuid:5b4e56f5-3294-42df-be51-51434d2d337d
- Local pid:
- pubs:869151
- Deposit date:
- 2018-12-05
Terms of use
- Copyright holder:
- Fryett et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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