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Comparison of methods for transcriptome imputation through application to two common complex diseases

Abstract:

Transcriptome imputation has become a popular method for integrating genotype data with publicly available expression data to investigate the potentially causal role of genes in complex traits. Here, we compare three approaches (PrediXcan, MetaXcan and FUSION) via application to genome-wide association study (GWAS) data for Crohn's disease and type 1 diabetes from the Wellcome Trust Case Control Consortium. We investigate: (i) how the results of each approach compare with each other and with ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41431-018-0176-5

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Role:
Author
ORCID:
0000-0003-3139-5466
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Inshaw, J
National Institutes of Health More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
European Journal of Human Genetics Journal website
Volume:
26
Issue:
11
Pages:
1658-1667
Publication date:
2018-07-05
Acceptance date:
2018-04-11
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
Pubs id:
pubs:869151
URN:
uri:5b4e56f5-3294-42df-be51-51434d2d337d
UUID:
uuid:5b4e56f5-3294-42df-be51-51434d2d337d
Local pid:
pubs:869151
Language:
English
Keywords:

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