Clinical outcome and pathologic correlation of stereotactic body radiation therapy as a bridge to transplantation for advanced hepatocellular carcinoma: a case series

Wang, Y-F; Dai, Y-H; Lin, C-S; Chang, H-C; Shen, P-C; Yang, J-F; Hsiang, C-W; Lo, C-H; Huang, W-Y

Journal article

Clinical outcome and pathologic correlation of stereotactic body radiation therapy as a bridge to transplantation for advanced hepatocellular carcinoma: a case series

Abstract:: Abstract Background Stereotactic body radiotherapy (SBRT) is an emerging modality for hepatocellular carcinoma (HCC). However, there is scant information about its safety and effectiveness in the neoadjuvant setting prior to liver transplantation (LT). We present the clinical outcome and pathologic assessment of SBRT followed by LT for patients with advanced HCC. Methods This retrospective study included HCC patients treated with neoadjuvant SBRT prior to LT between 2009 and 2018. Radiographic response and adverse effects, including radiation-induced liver disease (RILD), were evaluated. Pathologic response was assessed by the percentage of tumor necrosis relative to the total tumor volume. Overall survival (OS) and recurrence-free survival (RFS) were calculated using the Kaplan–Meier method. Results Fourteen patients underwent SBRT for a total of 25 HCC lesions, followed by LT. The median tumor size was 4.45 cm in diameter, and the median prescribed dose was 45 Gy in 5 fractions. SBRT provided significant AFP reduction, 100% infield control, and a 62.5% response rate. The maximum detected toxicity included grade 3 thrombocytopenia and two grade 3–4 hyperbilirubinemia. One patient developed non-classic RILD. Patients were bridged to LT with a median time of 8.4 months after SBRT, and 23.1% of them achieved a complete pathologic response. The median OS and RFS were 37.8 and 18.3 months from the time of LT, respectively. Conclusions SBRT provides favorable tumor control and acceptable adverse effects for patients awaiting LT. Further prospective studies to test SBRT as a bridging therapy for LT are feasible.

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

Wang, Y.-F., Dai, Y.-H., Lin, C.-S., Chang, H.-C., Shen, P.-C., Yang, J.-F., Hsiang, C.-W., Lo, C.-H., & Huang, W.-Y. (2021). Clinical outcome and pathologic correlation of stereotactic body radiation therapy as a bridge to transplantation for advanced hepatocellular carcinoma: a case series. Radiation Oncology, 16(1), 15.

MLA Style

Wang, Y-F, et al. “Clinical Outcome and Pathologic Correlation of Stereotactic Body Radiation Therapy as a Bridge to Transplantation for Advanced Hepatocellular Carcinoma: a Case Series.” Radiation Oncology, vol. 16, no. 1, 2021, p. 15.

Chicago Style

Wang, Y-F, Y-H Dai, C-S Lin, et al. 2021. “Clinical Outcome and Pathologic Correlation of Stereotactic Body Radiation Therapy as a Bridge to Transplantation for Advanced Hepatocellular Carcinoma: a Case Series.” Radiation Oncology 16 (1): 15.
Print