Journal article
Reductant-free cross-electrophile synthesis of di(hetero)arylmethanes by palladium-catalyzed desulfinative C–C coupling
- Abstract:
- An efficient Pd-catalyzed one-pot desulfinative crosscoupling to access medicinally relevant di(hetero)arylmethanes is reported. The method is reductant-free, and involves a sulfinate transfer reagent and a Pd-catalyst mediating the union of two electrophilic coupling partners; a (hetero)aryl halide and a benzyl halide. We establish for the first time that benzyl sulfinates, generated in situ, undergo efficient Pd-catalyzed desulfinative cross-coupling with (hetero)aryl halides to generate di(hetero)arylmethanes. The reaction can be extended to benzylic pseudohalides derived from benzyl alcohols. The reactions are straightforward to perform and scalable, and all reaction components are commercially available.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 4.3MB, Terms of use)
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- Publisher copy:
- 10.1002/ange.202116775
Authors
- Publisher:
- Wiley
- Journal:
- Angewandte Chemie International Edition More from this journal
- Volume:
- 134
- Issue:
- 19
- Article number:
- e202116775
- Publication date:
- 2022-03-14
- Acceptance date:
- 2022-02-24
- DOI:
- EISSN:
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1521-3773
- ISSN:
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1433-7851
- Language:
-
English
- Keywords:
- Pubs id:
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1241193
- Local pid:
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pubs:1241193
- Deposit date:
-
2022-02-25
- ARK identifier:
Terms of use
- Copyright holder:
- McKnight et al
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. Angewandte Chemie published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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