Journal article : Review
Uncovering viral RNA–host cell interactions on a proteome-wide scale
- Abstract:
- RNA viruses interact with a wide range of cellular RNA-binding proteins (RBPs) during their life cycle. The prevalence of these host–virus interactions has been highlighted by new methods that elucidate the composition of viral ribonucleoproteins (vRNPs). Applied to 11 viruses so far, these approaches have revealed hundreds of cellular RBPs that interact with viral (v)RNA in infected cells. However, consistency across methods is limited, raising questions about methodological considerations when designing and interpreting these studies. Here, we discuss these caveats and, through comparing available vRNA interactomes, describe RBPs that are consistently identified as vRNP components and outline their potential roles in infection. In summary, these novel approaches have uncovered a new universe of host–virus interactions holding great therapeutic potential.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 3.6MB, Terms of use)
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- Publisher copy:
- 10.1016/j.tibs.2021.08.002
Authors
+ European Commission
More from this funder
- Funder identifier:
- https://ror.org/00k4n6c32
- Funding agency for:
- Kamel, W
- Grant:
- 842067
+ Biotechnology and Biological Sciences Research Council
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- Funder identifier:
- https://ror.org/00cwqg982
- Funding agency for:
- Iselin, L
- Grant:
- BB/M011224/1
+ Medical Research Council
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- Funder identifier:
- https://ror.org/03x94j517
- Funding agency for:
- Palmalux, N
- Programme:
- MRC CVR PhD programme
+ Medical Research Council
More from this funder
- Funder identifier:
- https://ror.org/03x94j517
- Funding agency for:
- Castello, A
- Grant:
- MC_UU_12014/10
- MC_UU_12014/12
- MR/R021562/1
- MR/L019434/1
- Publisher:
- Cell Press
- Journal:
- Trends in Biochemical Sciences More from this journal
- Volume:
- 47
- Issue:
- 1
- Pages:
- 23-38
- Place of publication:
- England
- Publication date:
- 2021-09-09
- Acceptance date:
- 2021-08-06
- DOI:
- EISSN:
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1362-4326
- ISSN:
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0968-0004
- Pmid:
-
34509361
- Language:
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English
- Keywords:
- Subtype:
-
Review
- Pubs id:
-
1196612
- Local pid:
-
pubs:1196612
- Deposit date:
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2025-02-27
- ARK identifier:
Terms of use
- Copyright holder:
- Iselin et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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