Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.

Journal article

Injection of mice transgenic for a class I major histocompatibility complex-restricted T-cell receptor with a soluble peptide antigen from influenza virus nucleoprotein results in clonal depletion of double-positive immature thymocytes in the thymus and activation of mature T cells in the periphery, accompanied by a transient up-regulation of the T-cell receptor and CD3 and CD8 coreceptor molecules.

Authors: Mamalaki, C; Norton, T; Tanaka, Y; Townsend, A; Chandler, P

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 89
• Issue: 23
• Pages: 11342-11346
• Publication date: 1992-12-01
• DOI: 10.1073/pnas.89.23.11342
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Solubility; Nucleocapsid Proteins; Antigens, Viral; CD4-Positive T-Lymphocytes; Gene Expression; Mice, Transgenic; Lymphocyte Activation; Antigens, CD3; Histocompatibility Antigens Class I; Animals; Lymph Nodes; Receptors, Antigen, T-Cell, alpha-beta; Thymus Gland; Orthomyxoviridae; Nucleoproteins; Viral Core Proteins; Mice; Antigens, CD8; Peptides; T-Lymphocyte Subsets