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Clinical pharmacokinetics of cardiac glycosides in patients with renal dysfunction.

Abstract:

The pharmacokinetics of different cardiac glycosides are altered by renal dysfunction in different ways, depending on their basic pharmacokinetic properties. Digoxin: The linearity of digoxin pharmacokinetics is unchanged by renal dysfunction, as is the bioavailability. Protein binding may be slightly reduced, but the change is of no clinical significance. The apparent volume of distribution is reduced by one-third to one-half, the change being roughly proportional to the degree of renal impa...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
Journal:
Clinical pharmacokinetics
Volume:
8
Issue:
2
Pages:
155-178
Publication date:
1983
DOI:
ISSN:
0312-5963
URN:
uuid:5af36b31-9517-4663-b5b8-65b7fee12eeb
Source identifiers:
322101
Local pid:
pubs:322101

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