The pharmacokinetics of different cardiac glycosides are altered by renal dysfunction in different ways, depending on their basic pharmacokinetic properties. Digoxin: The linearity of digoxin pharmacokinetics is unchanged by renal dysfunction, as is the bioavailability. Protein binding may be slightly reduced, but the change is of no clinical significance. The apparent volume of distribution is reduced by one-third to one-half, the change being roughly proportional to the degree of renal impa...Expand abstract
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Clinical pharmacokinetics of cardiac glycosides in patients with renal dysfunction.
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