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Journal article

The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension.

Abstract:

Binding of the nuclear factor-Y complex (NF-Y) to the inverted CCAAT-box interferes with transcription activation through nucleosome reorganization. The three homologous proteins forming the zinc-fingers and homeoboxes (ZHX) family interact with the activation domain of NF-Ya to repress transcription. Each ZHX-protein contains two generic C2H2 zinc-fingers (ZNF1 and ZNF2) followed by five homeodomains. Although the proteins have been related to the occurrence of certain cancers, the function ...

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Publication status:
Published

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Publisher copy:
10.1021/bi9001997

Authors


Lammers, I More by this author
Wechselberger, RW More by this author
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Journal:
Biochemistry
Volume:
48
Issue:
21
Pages:
4431-4439
Publication date:
2009-06-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:5aefeee2-f87c-4a97-9694-73776208d550
Source identifiers:
72655
Local pid:
pubs:72655

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